Set them free: F-box protein exchange by Cand1
نویسندگان
چکیده
منابع مشابه
Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins
The modular SCF (Skp1, cullin, and F box) ubiquitin ligases feature a large family of F box protein substrate receptors that enable recognition of diverse targets. However, how the repertoire of SCF complexes is sustained remains unclear. Real-time measurements of formation and disassembly indicate that SCF(Fbxw7) is extraordinarily stable, but, in the Nedd8-deconjugated state, the cullin-bindi...
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Cullin-RING ubiquitin ligase complexes (CRLs) rely on a vast array of adaptor proteins to recognize their substrates. Pierce et al. and related papers from Zemla et al. and Wu et al. in Nature Communications show that Cand1 promotes exchange of adaptor proteins to regulate the CRL repertoire.
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Ubiquitin E3 ligases represent an increasingly diverse group of proteins whose precise biologic role still remains enigmatic. Of the SCF (Skp1-Cullin1-F-box) E3 ligase family, for example, only very few subunits from over 60 family members are well-characterized. The SCF apparatus contains a multi-subunit catalytic core consisting of Skp1, Cullin1 and the E2 ubiquitin-conjugating (Ubc) enzyme a...
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Cullin RING ligases are multi-subunit complexes consisting of a cullin protein which forms a scaffold onto which the RING protein Rbx1/2 and substrate receptor subunits assemble. CAND1, which binds to cullins that are not conjugated with Nedd8 and not associated with substrate receptors, has been shown to function as a positive regulator of Cullin ligases in vivo. Two models have been proposed ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2013
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2013.55